https://www.cantonelab.org/home daily 1.0 2024-06-27 https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/11c42b81-c5a9-49c1-9ab1-b68a59e2c5a3/smaller+logo+home+page.jpg HOME https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/e53eb388-f8d1-453e-9a4e-6c3afe7e391d/XIST+on+the+sea_crop.jpg HOME https://www.cantonelab.org/about daily 0.75 2024-07-07 https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/e5ef6e75-6a35-45f3-b31d-c984309b78d7/labwebpari.jpg The Team - Parichitran Ayyamperumal from Thamil (India) started on May 2024… loading! Hi, I am Parichitran Ayyamperumal, hailing from India. I am in pursuit of understanding how a cell differentiates in both developmental and disease contexts. I approach this through the lens of X-chromosome inactivation, transcriptional bursting, and Random Monoallelic Expression (RME). To achieve this, I extensively utilize multi-omic datasets and establish pipelines for their analysis. Previously, I have shown that the two alleles of a gene can transcriptionally burst together to fine-tune their gene expression (Ayyamperumal et al., LifeScience Alliance, 2024). Additionally, I explored RME in Triple Negative Breast Cancer (TNBC) and its association with tumor heterogeneity, which is responsible for their pathogenic outcomes (Ayyamperumal et al., bioRxiv, 202X). Currently, I am working to understand cellular heterogeneity in human autoimmune diseases, cancer, and other conditions. In my free time, I enjoy traveling and playing basketball. https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/1619637099964-7974C04U9NBJ99YCTE16/IMG_3564.jpg The Team https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/1619510043383-2KY827PEA9JFYSU1Y1IS/IMG_0774.JPG The Team Thanks to Joan and Lucia for the pic @Galapagos islands! https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/a09eb75c-020f-404b-a89a-99f37d19c249/IMG_6793.jpeg The Team - My name is Anna and I am a BSC student in Biotecnhology for health at the University of Naples Federico II. I’m an expansive, curious and ambitious girl. In my free time I’m a dancer… I also love watching movies, visiting museums and spending time with the people I love. I am an exaggerated perfectionist and I endeavour to achieve my dreams. One of these is becoming a researcher: I want to help others through science. In the laboratory I have the fortune to investigate all the epigenetic mechanisms that are underlying the sex bias in autoimmune diseases. My name is Anna and I am a BSC student in Biotecnhology for health at “Federico II” University. I’m an expansive, curious and ambitious girl. In my free time I’m a dancer… I also love watching movies, visiting museums and spending time with the people I love. I am an exaggerated perfectionist and I endeavour to achieve my dreams. One of these is becoming a researcher: I want to help others through science. In the laboratory I have the fortune to investigate all the epigenetic mechanisms that are underlying X chromosome’s reactivation in autoimmune diseases. https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/fe442046-2239-4fbb-8e65-9cec1a2d1f4e/IMG_0947+%281%29.jpg The Team - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.cantonelab.org/services daily 0.75 2025-10-17 https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/7c3ea850-1666-41a7-b4b6-f9d9244366ff/Logo_MUR_new.jpg Our Publications and Funding - We have been awarded a grant from the Italian Ministry of University and Reaserch to investigate the role of epigenetics and X chromosome inactivation in the control of regulatory T cell function https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/1619500110606-J7P53UBLMUUPH3I7687L/xist.jpg Our Publications and Funding https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/bba510d1-0743-404c-bb93-96bd70c66138/IMG_6802.png Our Publications and Funding - Thanks to the Italian Foundation for Multiple Sclerosis (FISM) we are now granted over 360k to study the impact of XCR in the female prevalence of Multiple Sclerosis. https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/1c3a00ee-f0f2-4cae-84df-7c12e4a060c6/download.png Our Publications and Funding - We have been awarded 250k$ to investigate the role of X chromosome inactivation and escape in Multiple Sclerosis https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/6980f0e8-efed-4df8-9415-78b71b6b961b/3481527957.jpg Our Publications and Funding - We have been awarded a grant from AFM telethon to investigate the mechanisms of X chromosome reactivation in X-linked genetic diseases https://www.cantonelab.org/residential daily 0.75 2024-05-27 https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/3cdb360b-e7dc-45d2-8fd7-c2bebf3f6c94/Cell+cycle+hF+XIST.jpg X chromosome Reactivation XIST delocalization during somatic cell cycle (modified from Cantone et al., Nature Comm 2016) https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/1619673067383-OOKN98MAZONTIQB1QHCQ/XIST+scheme.jpg X chromosome Reactivation XIST delocalization during cell fusion-mediated somatic cell reprogramming is associated with Xi gene reactivation (Cantone I, Phil Trans of Royal Society 2017) https://www.cantonelab.org/commercial daily 0.75 2024-03-21 https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/1619444181899-BHTUTTL6V22GHL5CG9QK/SSEA4+hES+colony.tif+%28RGB%29.jpg Human pluripotent reprogramming https://www.cantonelab.org/experiential daily 0.75 2024-05-27 https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/1619457674757-0R13Y9Z3FBJGJRFT0ZLT/Figure.jpg Epigenetics of Sex-biased diseases https://www.cantonelab.org/experiential-1 daily 0.75 2021-04-26 https://images.squarespace-cdn.com/content/v1/5ce2e1b47977970001d9545e/1558471325414-WU05TRG9JWV0E62OAV83/download+copy+2.jpeg Epigenetics of Sex-bias (Copy) https://images.squarespace-cdn.com/content/v1/5ce2e1b47977970001d9545e/1560288303310-TTJEIL1U469UY7OCHUMY/Stocksy_txp9c995bd1cMI100_Large_1192042.jpg Epigenetics of Sex-bias (Copy) https://images.squarespace-cdn.com/content/v1/5ce2e1b47977970001d9545e/1560288335378-1RLP8C2OBC0QXC2Q0QA3/Stocksy_txp9c995bd1cMI100_Large_1192029.jpg Epigenetics of Sex-bias (Copy) https://images.squarespace-cdn.com/content/v1/5ce2e1b47977970001d9545e/1560288373735-NRNSJ40PIZ23YJQJI5CV/Stocksy_txp9c995bd1cMI100_Large_1183977.jpg Epigenetics of Sex-bias (Copy) https://www.cantonelab.org/therapeutic-routes daily 0.75 2024-05-27 https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/1619458291639-394DWSNS3KB1O2UFWSN5/Slide17.jpg Therapeutic Routes https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/1619458145890-X9ATRHX6FUYNCQONX3IS/Cantone_DBBM_2020_Page_1.jpg Therapeutic Routes https://www.cantonelab.org/contact daily 0.75 2022-10-04 https://www.cantonelab.org/contact-1 daily 0.75 2024-09-02 https://www.cantonelab.org/vacancies daily 0.75 2025-03-07 https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/1ed296be-d80e-446c-bceb-8e5144e611e0/Cantone+Computational+Postdoc+2025.jpg Vacancies - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/1621247527965-2O3SDXZ1Y45Z6Z28L09M/DSC_4628.jpg Vacancies https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/e34589af-2d75-440d-ba72-36912213c6ef/IMG_6533.jpeg Vacancies - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.cantonelab.org/lab-news-and-evenets daily 0.75 2024-06-27 https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/33e0f3d5-dc9d-48f3-b920-2d20feb4e5a7/IMG_0921.jpg https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/45e36151-b967-4dae-9c16-a2d108f93b50/IMG_0947+%281%29.jpg https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/a8d5baf3-6a4c-41cb-9214-17c0c942ce83/Anna+at+FISM.jpg https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/ce03c9e8-f0ce-4c19-8089-a08bcbc6cab1/Welcome+Pari%21.jpg https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/b77b8afb-016d-4b9b-b61e-f04c3c914ed3/Frittata+di+pasta.jpg https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/b1b420f4-9ac0-482d-9e0c-c293cb4ef96f/Black+hole+in+sagittarius.jpeg https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/50e5dc44-7eeb-4d67-b814-3233bf1ca611/IMG_7898.jpg https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/f4773f44-02df-4882-abca-bd67568f8b69/21EA3312-7249-45C7-8B02-66291E50570F.JPG https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/764ccf5c-cc51-448e-a748-19a5b7c653f3/Secret+santa+2023.JPG https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/9e391b16-b762-43e4-883f-59857f1dd1b0/Sentiero+degli+dei_COLLAGE.jpg https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/69a19f7d-6ec9-4017-87d8-d5ac25e30edd/sept+2023.JPG https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/5c29c580-a013-46fc-b535-6d5b3e212a2b/1520232569647.jpg https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/0642ef68-147c-4748-acf8-abf9934d893c/XCI_Berlin_2023.jpg https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/719111e2-028a-4f7d-aa81-cbe492b01f1b/Screenshot+2023-06-17+at+10.33.00.png https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/e75f8021-eacd-4319-a8e3-0f43243ead75/Screenshot+2022-10-04+at+14.39.43.png https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/a6dadcda-315d-430d-a748-a02ae1ed238c/Sept+2022_2.jpg https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/044c2aae-5e97-4631-a85e-367ca60fb751/Vince_Marty.jpg https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/5203fb34-59f7-43e3-9d9b-98c3cc1b5cf2/Vince.jpg https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/77cb207e-1f13-41a0-921b-0025e164eac6/Lab+moving.jpeg https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/b4a939ae-95bf-4b97-9a2a-6d34f35e9541/Martina.jpg https://images.squarespace-cdn.com/content/v1/608578d25da00b5dee2ef1cb/620bf7f5-b37b-480e-8185-adea3e3dd86b/e7f34bc8-03e9-45c9-b9ff-22afaa663466.JPG